Tetrel‐Centered Exchange Cascades to Decouple Inhibition and Induction of Thiol‐Mediated Uptake: Introducing Cell‐Penetrating Thiolactones, Focus on Reversible <i>Michael</i> Acceptor Dimers

This study adds thiolactones to the collection of cascade exchangers (CAXs) and reports with dynamic covalent Michael acceptor dimers first CAXs that rather inhibit than enable thiol-mediated uptake. The superior performance compared monomeric acceptors as inhibitors might suggest top move along thiol/ate arrays without losing contact, while cell penetrators exchange disulfide arrays. decoupling inhibition induction uptake is important because latter promising for drug delivery, former possibly helps reveal targets associated antiviral, antithrombotic antitumor activity, leading discovery. These results are consistent working model a general complex network in charge bringing matter into cells, thus support its validity.